There has been the report of a an important discovery, that can be regarded as a breakthrough in the recent days by the collaborative effort of the eminent researchers from the National Institute of Environmental Health Sciences, better known as NIEHS and the Umeö University in Sweden. It has come out that there has been a through detection of a vital new role that an enzyme called DNA polymerase epsilon star as in the very process of replication of the DNA in higher organisms for instance in yeast and conceivably also even in the human beings. It is to be noted according to the info that the investigative study in its entirety was jointly conducted by Dr. Zachary Pursell and Dr. Thomas A. Kunkel at NIEHS while being assisted by Dr. Erik Johansson in conjunction with his colleagues at the Umeå University.

While having a detailed discussion over the course of the entire investigation it has been revealed that there has been the effective application of an innovative strategy on the part of the group of researchers. The sole intention has been to demonstrate that in bakers yeast, DNA polymerase epsilon do perform prominent function while being engaged in the methodology of replicating the leading strand of DNA. But now the question is what has been or rather to be more precise the greatest purpose of the DNA polymerase? The DNA polymerase epsilon was found designated as a viable and key substratum of genome stability and of cellular responses to DNA damage, which results greatly from the general exposures to environmental stress. In addition, the researchers depended largely on the fundamental discoveries on the structure and replication of DNA, that was the novel finding made by Nobel laureates James Watson, Francis Crick and Arthur Kornberg. But When Watson and Crick happened to first describe the structure of DNA in 1953, they came out with the definite pointing out of the two DNA strands, that in due course has been referred to as leading and lagging, pair with each other to form the now familiar double helix.

Dr. David A. Schwartz M.D., the Director of NIEHS, a distinguished component of the National Institutes of Health said, "The study places us one step closer to understanding the origins of genome instability that underlie certain environmental diseases in humans." On the other hand, Dr. Kunkel, the prominent author and Chief, Laboratory of Structural Biology at NIEHS said, "Amazingly, more than a half century after Watson and Crick first described the DNA double helix, it had remained unclear which of these many DNA polymerases in higher organisms is actually responsible for first replicating the leading strand during nuclear genome duplication. "