In the recent days we come across a good number of diseases of which we were hardly aware in the earlier days. On of these diseases is lupus, which by and large has assumed a gigantic proportion thanks to the rapidly changing health scenario in the international arena. It is a acute autoimmune disorder that has been duly recognized in the world over while affecting thousands of young and middle-aged people year on year at large, and most of them happen to be female it has also been found in this regard, that a permutation of high-dose chemotherapy and stem-cell transplantation could be an useful device in the treatment of severe lupus.

For the true assessment and expunging of this disease a great many researches do happen. In the recent days likewise a group of eminent researchers of the Northwestern University Medical School headed by Dr. Ann Traynor, M.D. in conjunction with his colleagues accomplished the process of evaluation of the protection and worth of high-dose immune suppression and stem-cell transplantation in patients affected with this disease of lupus. According to them, if there happens to be an average but rigorous follow-up for two years at a stretch after the very treatment, the patients generally become free from the active signs of active lupus and their kidney, heart, lung and immune system function tend to remain normal. It is to be noted in this respect that stem cells are "mother cells," or progenitors, that are comprised of the capacity for the expansion and differentiation into many types of cells, that include infection-fighting T and B cells.

It is from the year 1996, the researchers selected seven patients affected with insistent lupus that persisted in spite of the use of cyclophosphamide, a potent immunosuppressant drug. Throughout the course of action the patients had undergone high-dose of immune suppression and as a whole received infusions of stem cells that they had donated before the receiving of immunosuppressive therapy. The patients' circulating white blood cells were analyzed before and after transplantation.

Speaking on this occasion Dr. Traynor said, "What is exciting about this observation is that it appears that the immune system can correct its errors if early stem cells are allowed to mature as naive cells in a 'neutral' environment."